- Franklin Chang-Diaz, '73 (ENG), NASA astronaut and veteran of seven space flights
- Scott Cowen, '68 (BUS), President of Tulane University
- Charles Duelfer, '74 (CLAS), Director of Central Intelligence Special Advisor for Strategy regarding Iraqi Weapons of Mass Destruction Program
- Ned Kahn, '82 (CANR), prominent sculptor and scientist
- Robert Kaplan, '73 (CLAS), correspondent for Atlantic Monthly and best-selling author
- David M. Lee, '55 MS, 1996 co-winner of the Nobel Prize for Physics
- Michael Maslin, '76 (SFA), cartoonist for New Yorker Magazine
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- Richard Mastracchio, '82 (ENG), mission specialist for NASA who flew his first space shuttle mission in September of 2000, unveiling a UConn flag on the international space station
- Les Payne, '64 (CLAS), associate managing editor and syndicated columnist for Newsday and a Pulitzer Prize Award recipient in 1974
- Joseph W. Polisi, '69 (CLAS), President of the Julliard School of Music
- Carolyn Runowicz, MD, '73 (CLAS), President of the American Cancer Society
- Paige Turco (SFA), '88, television and film actress
- Dona D. Young '80 J.D., Chairman, President and Chief Executive Officer of The Phoenix Companies, Inc.
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